BCPS Non-Clinical Practice Test 2026 – Complete Exam Prep

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In Cockcroft-Gault CrCl calculation, which female adjustment is applied?

(140 - age) x weight x 0.85 / (72 x SCr)

The key idea is that the Cockcroft-Gault estimate includes a sex-specific adjustment to account for differences in muscle mass and creatinine production. For females, you multiply by 0.85, reflecting generally lower muscle mass than males. So the female-adjusted formula is CrCl = [(140 − age) × weight × 0.85] / (72 × SCr). This lowers the CrCl estimate compared with the male version, which uses no extra factor.

Omitting the 0.85 would overestimate renal clearance in women, while using 0.75 or 0.95 would introduce an incorrect adjustment not supported by the standard equation. For example, with age, weight, and serum creatinine plugged in, the 0.85 factor reduces the numerator appropriately to reflect female physiology.

(140 - age) x weight / (72 x SCr)

(140 - age) x weight x 0.75 / (72 x SCr)

(140 - age) x weight x 0.95 / (72 x SCr)